Document ID: CL-WP-002 | Rev A | Author: Michael Pitsakis | Advisors: Dr. Ralf Marbach & Dr. Robert Norwood

DECOUPLING CHEMISTRY FROM DIAGNOSTICS: The Reagent-Free Future of POC

The global diagnostics industry has a massive structural flaw: it is built almost entirely upon recurring consumable chemistry. Every diagnostic event—whether utilizing a point-of-care glucose strip, a urinalysis dipstick, or a blood gas cartridge—consumes chemistry, introducing severe margin degradation, cold-chain supply constraints, and biohazardous waste. CoraLuma’s latest white paper, Decoupling Chemistry from Diagnostics: Reagent-Free Analysis Through Computational Biophotonics, challenges this legacy model. The paper introduces CoraLuma’s investigational System 4 platform, which utilizes a high-SNR (>120 dB) static fluid caliper for the direct optical interrogation of whole blood, plasma, and urine. By executing Orthogonal Signal Correction (OSC) to subtract the dominant physiological baseline, and projecting the corrected spectra into our Matérn 5/2 Gaussian Process Regression (GPR), System 4 establishes visibility of low-amplitude target signatures without inducing a chemical reaction. This architecture establishes a pathway for instant optical cultures, reagent-less urinalysis, and solid-state toxicology—proving that the future of diagnostics will be driven by physics, not high-COGS chemistry.

For full article 03_CL-WP-003-RevA_Decoupling_Chemistry_from_Diagnostics.pdf, click the link below.
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